Trypsin-like Immunoreactivity Levels In Your Dog And Cat













Ron Hines DVM PhD

To see what normal blood and urine values are, go here

For an explanation of causes of most abnormal blood and urine tests, go here

To see how tests are grouped, go here

cTLI and fTLI

Canine or Feline Trypsin-like Immunoreactivity In Your Pet’s Blood

Just like the fPL and the cPL tests offered by Idexx laboratories, the TLI test detect abnormal leakage of lipase digestive enzyme into your pet’s blood or the lack of the enzyme in pancreatic failure. The trypsinogen or trypsin-like immunoreactivity test (TLI) detects leaked trypsin digestive enzyme that have leaked out of an injured pancreas.

In dogs and cats, elevated levels in all of these tests are most commonly associated with acute pancreatic problems (acute pancreatitis) and lowered levels to pets with chronic pancreatic problems (EPI). But abnormal levels either way usually point toward the pancreas as the source of problems.

Cats with inflammatory bowel disease (IBD) triad disease, and cholangiohepatitis often have pancreatic problems as part of their disease - so their tests can also be above or below normal.


Reasons Your Pet’s TLI Levels Could Be Low :

Chronic inflammation of the portion of your pet’s pancreas that produces digestive enzymes (EPI),
Triad disease, cholangiohepatitis and inflammatory bowel disease in cats (IBD) (IBD rarely increases TLI levels in dogs), pancreatic tumors

Some dogs develop antibodies that are directed against their own pancreas (PAA, an autoimmune disease). Those pets may loose the ability to produce pancreatic trypsin. (ref)

Occasionally, TLI levels will be abnormally low (or high) in cats ill from non-pancreatic causes.

Reasons Your Pet’s TLI Levels Could Be High :

Acute or chronic Pancreatitis in dogs and cats, inflammatory bowel disease (IBD), Triad disease and cholangiohepatitis in cats, failing kidneys, malnutrition in dogs, pancreatic hypertrophy in cats. (notice that some of these diseases can make TLI levels go up or down.)

Complementary Tests:

Serum amylase and lipase, fPL and cPL tests, repeat the pet's TLI in one month, abdominal ultrasound, blood cobalamin and folate levels, pancreatic biopsy, a normal TLI does not entirely rule out pancreatic problems in your pet