Times change and my website needed to change too. To see the 2020 update of this page click this link
To see what normal blood and urine values are, go here
For an explanation of causes of most abnormal blood and urine tests, go here
To see how tests are grouped, go here
Canine or Feline Trypsin-like Immunoreactivity In Your Pet’s Blood
Just like the fPL and the cPL tests offered by Idexx laboratories, the TLI test detect abnormal leakage of lipase digestive enzyme into your pet’s blood or the lack of the enzyme in pancreatic failure. The trypsinogen or trypsin-like immunoreactivity test (TLI) detects leaked trypsin digestive enzyme that have leaked out of an injured pancreas.
In dogs and cats, elevated levels in all of these tests are most commonly associated with acute pancreatic problems (acute pancreatitis) and lowered levels to pets with chronic pancreatic problems (EPI). But abnormal levels either way usually point toward the pancreas as the source of problems.
Cats with inflammatory bowel disease (IBD) triad disease, and cholangiohepatitis often have pancreatic problems as part of their disease - so their tests can also be above or below normal.
of the portion of your pet’s pancreas that produces digestive enzymes
Triad disease, cholangiohepatitis and inflammatory bowel disease in cats (IBD) (IBD rarely increases TLI levels in dogs), pancreatic tumors
Occasionally, TLI levels will be abnormally low (or high) in cats ill from non-pancreatic causes.
Acute or chronic Pancreatitis in dogs and cats, inflammatory bowel disease (IBD), Triad disease and cholangiohepatitis in cats, failing kidneys, malnutrition in dogs, pancreatic hypertrophy in cats. (notice that some of these diseases can make TLI levels go up or down.)
Serum amylase and lipase, fPL and cPL tests, repeat the pet's TLI in one month, abdominal ultrasound, blood cobalamin and folate levels, pancreatic biopsy, a normal TLI does not entirely rule out pancreatic problems in your pet